This volume brings together the primary challenges for 21^st century cognitive sciences and cultural neuroscience in responding to the nature of human identity, self, and evolution of life itself. Through chapters devoted to intricate but focused models, empirical findings, theories, and experiential data, the contributors reflect upon the most exciting possibilities, and debate upon the fundamental aspects of consciousness and self in the context of cultural, philosophical, and multidisciplinary divergences and convergences. Such an understanding and the ensuing insights lie in the cusp of philosophy, neurosciences, psychiatry, and medical humanities. In this volume, the editors and contributors explore the foundations of human thinking and being and discuss both evolutionary/cultural embeddedness, and the self-orientation, of consciousness, keeping in mind questions that bring in the interdisciplinary complexity of issues such as the emergence of consciousness, relation between healing and agency, models of altered self, how cognition impacts the social self, experiential primacy as the hallmark of consciousness, and alternate epistemologies to understand these interdisciplinary puzzles.