Randomized Phase II Cancer Clinical Trials

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Randomized Phase II Cancer Clinical Trials

Research methods: general Clinical trials Epidemiology and Medical statistics Oncology

Author: Sin-Ho Jung

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Collection: Chapman & Hall/CRC Biostatistics Series

Language: English

Published by: Chapman and Hall/CRC

Published on: 2nd May 2013

Format: LCP-protected ePub

ISBN: 9781040186978


In cancer research

A traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biosta

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