This two-volume set LNAI 16121-16122 constitutes the proceedings of the 24th EPIA Conference on Progress in Artificial Intelligence, EPIA 2025, held in Faro, Portugal, during October 1–3, 2025.The 76 full papers included in these proceedings were carefully reviewed and selected from 158 submissions. They were organized in topical sections as follows:Part I: Artificial Intelligence in Medicine (AIM); AI for Architecture, Engineering and Conservation (AI4AEC); Knowledge Discovery and Business Intelligence (KDBI); Generative AI: Foundations and Applications (GenAI); Artificial Intelligence: Theory, Methods, and Applications (AITMA); Ethics and Responsibility in AI (ERAI).Part II: Artificial Intelligence for Industry and Societies (AI4IS); Artificial Intelligence and Law (AIL); Artificial Intelligence and IoT in Agriculture (AIoTA); Artificial Intelligence in Transportation Systems (AITS); Natural Language Processing, Text Mining and Applications (NLP-TeMA); Ambient Intelligence and Affective Environments (AmIA); AI and Creativity (AIC); Artificial Intelligence in Power and Energy Systems (AIPES); Fuzzy Data Analysis and Applications (FDA).