This volume LNCS 14615 constitutes the refereed proceedings of the 10th International Conference on Modelling and Simulation for Autonomous Systems, MESAS 2023, in October 17–19, 2023, in Palermo, Italy.

The 21 full papers presented together with 4 short papers were carefully reviewed and selected from 49 submissions. The conference focuses to to unite the Modelling and Simulation and the Autonomous Systems/Robotic communities, creating a space for the exchange of innovative ideas and concept development.