This book constitutes the thoroughly refereed post-conference proceedings of the 7th International Conference on Modelling and Simulation for Autonomous Systems, MESAS 2020, held in Prague, Czech Republic, in October 2020.

The 19 full papers included in the volume were carefully reviewed and selected from 26 submissions. They are organized in the following topical sections: future challenges of advanced M&S technology; M&S of intelligent systems – R&D and application; and AxS/AI in context of future warfare and security environment.

The conference was held virtually.