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Mitochondrial Genomics
Insights into Dysfunction and Disease
Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases
All 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models.
This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics.
Structural Organization and Animal Models
Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models.
Role of Mitogenomics in Diseases
Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer.
Future Perspectives and Methodologies
The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria.
Target Audience and Applications
Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics.
Key Topics
- Introduces mitochondrial genetics and function using animal models
- Discusses the role of mitogenomics in various disease states
- Considers the implication of whole mitochondrial genome sequencing in animals
- Explores mitochondrial replacement theory and gene editing
