This book comprises papers written in English and accepted for presentation and discussion at the 2025 International Conference on Information Technology & Systems (ICITS'25), held at Instituto Politécnico Nacional (IPN), Mexico City, Mexico, from January 22 to 24, 2025.ICITS'25 serves as a global forum for researchers and practitioners to present and discuss recent findings, innovations, current trends, professional experiences, and challenges in modern information technology and systems research, along with their technological developments and applications.The main topics covered include: Information and Knowledge Management; Organizational Models and Information Systems; Software and Systems Modeling; Software Systems, Architectures, Applications, and Tools; Multimedia Systems and Applications; Computer Networks, Mobility, and Pervasive Systems; Intelligent and Decision Support Systems; Big Data Analytics and Applications; Human-Computer Interaction; Ethics, Computers, and Security; Health Informatics; Information Technologies in Education; Media, Applied Technology, and Communication.The primary audience for this book includes postgraduate students and researchers in the field of Information Systems and Technologies. The secondary audience consists of undergraduate students and professionals working in related domains.