This book constitutes the thoroughly refereed proceedings of the international workshops associated with the 33rd International Conference on Advanced Information Systems Engineering, CAiSE 2021, which was held during June 28-July 2, 2021. The conference was planned to take place in Melbourne, Australia, but changed to an online format due to the COVID-19 pandemic.

The workshops included in this volume are:

•         BC4IS: 1st International Workshop on Blockchain for Information Systems
•         EMoBI: 3rd International Workshop on Ethics and Morality in Business Informatics
•         KET4DF: 3rd International Workshop on Key Enabling Technology for Digital Factories
•         MOBA: 1st International Workshop on Model-driven Organizational and Business Agility
•         NeGIS: 2nd International Workshop on Next Generation Information Systems

They focus on topics and trends ranging from blockchain technologies to digital factories, ethics, and business agility to the next generation of information systems.

The 14 full papers and 1 short paper presented in this volume were carefully reviewed and selected from 33 submissions.