First published in 1986: This two-volume set provides essential information on the general principles of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modification and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologists, pharmacologists, biochemists, and environmental toxicologists.