Serine Proteases and Human Disease

Serine proteases play significant roles in health and human disease. Abnormal expression and activities of serine proteases have been linked to the pathogenesis of many diseases. The book presents a correlation between serine proteases and human diseases. It helps the reader understand classification, catalytic mechanism, and types of serine proteases and their role in human disease pathogenesis at a mechanistic level.

The chapters explain the role of serine proteases in various diseases including respiratory disorders and cancer. It also covers the therapeutic importance of serine proteases as drug targets and explains the mechanistic insights of serine protease inhibitors.

Serine proteases are known to play a crucial role in biological processes, but disturbance in their equilibrium can result in serious health conditions. To maintain homeostasis, serine protease inhibitors come into action and inhibit proteases. Several serine protease inhibitors have been identified, and many more are being designed as novel compounds for inhibitions of proteases that provide management of comorbidities.

Therefore, this book will serve as a useful reference for students and researchers to understand the physiological role of serine proteases and their association with the initiation and progression of human diseases. It will also help to develop strategies to create serine protease inhibitors as drug targets at cellular and molecular levels.