Overview

This book explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies.

Clustered Studies

For clustered studies, the authors provide sample size formulas that account for variable cluster sizes and within-cluster correlation.

Longitudinal Studies

For longitudinal studies, they present sample size formulas that account for within-subject correlation among repeated measurements and various missing data patterns.

Multiple Levels of Clustering

For multiple levels of clustering, the authors describe how randomization impacts trial administration, analysis, and sample size requirement.