Reeling from a tragic ending to a serial murder case (Beyond Evil) in San Antonio, Texas, Frank McLaughlin, a worldly and highly skilled private investigator relocates to Dallas.

He settles in by building a new life with new friends until he takes on a missing person case. The client, Johnny Blue Feather, is a wealthy avionics entrepreneur of Native-American descent (Navajo) who wants to find and reunite his missing sister, Carol, with her two children. She had dropped her children off with an aunt more than a decade ago and ran away to live among the homeless in Albuquerque, New Mexico.

The case leads Frank on an odyssey along nostalgic Route 66 and deep into the Navajo Reservation where he is forced to confront Native-American culture, religion and history. His subject, Carol, is a proud survivor harboring a murderous secrete that is oddly linked to a vile skin-walker.

Franks obsession to learn her secrete takes him down a deadly path filled with intrigue and suspense. A street-wise prostitute (Tina) becomes his strongest ally while she desperately tries to turn her own life around.