This book provides a comprehensive, practical, and state-of-the art review addressing the major issues and challenges in cytopathology practice using a question and answer format. Making an accurate diagnosis, especially on a limited cytology sample obtained by minimally invasive procedures, is often challenging, yet crucial to patient care. Using the most current and evidence-based approaches, this book: 1) focuses on frequently asked questions in day-to-day practice of cytopathology as well as surgical pathology; 2) provides quick, accurate, and useful answers; 3) emphasizes the importance of clinical, radiological, and cytological correlation, as well as cyto-histological correlation; and 4) delineates how to judiciously use immunohistochemistry, molecular tests, flow cytometry, cytogenetics, and other established ancillary studies including next generation sequencing and computer-assisted diagnostics. Chapters are written by experts in their fields and provide the most up-to-date information in the field of cytopathology. Practical Cytopathology: Frequently Asked Questions serves as a practical resource and guide to relevant references for trainees, cytotechnologists, and cytopathologists at various skill levels.