Post-Authorization Safety Studies of Medicinal Products: The PASS Book

Bridges the gap in the literature by providing a complete look at post-authorization safety studies and important pharmacoepidemiology and pharmacovigilance aspects. It covers various types and limitations of active surveillance programs, including the use of large databases and disparate data sources for rapid signal detection, as well as novel and advanced design and analysis approaches for causal interference from observational data. This book serves as an important reference for pharmacovigilance scientists and pharmacoepidemiologists who are searching for the appropriate study design to answer safety research questions. Readers will be able to effectively and efficiently design and interpret findings from post-authorization safety studies with the goal of improving the benefit-risk balance of a drug in order to optimize patient safety.

Types of Observational Studies in Post-Marketing Drug Safety Assessment

Discusses all types of observational studies in post-marketing drug safety assessment, from spontaneous reporting systems, to pragmatic trials, with examples from real-world settings.

Post-Authorization Safety Studies

Presents various types of post-authorization safety studies.

Design and Conduct Challenges

Offers solutions to the common challenges in the design and conduct of these studies.

Active Surveillance Programs

Highlights active surveillance programs, including common data models for rapid signal detection of drug safety issues.