Provides a tutorial on the computational tools that use mathematical optimization concepts and representations for the curation, analysis and redesign of metabolic networks

Organizes, for the first time, the fundamentals of mathematical optimization in the context of metabolic network analysis

Reviews the fundamentals of different classes of optimization problems including LP, MILP, MLP and MINLP

Explains the most efficient ways of formulating a biological problem using mathematical optimization

Reviews a variety of relevant problems in metabolic network curation, analysis and redesign with an emphasis on details of optimization formulations

Provides a detailed treatment of bilevel optimization techniques for computational strain design and other relevant problems