Summary of a Workshop on Mississippi River Water Quality Science and Interstate Collaboration summarizes presentations and discussions of Mississippi River and basin water quality management, monitoring, and evaluation programs that took place at a workshop that was held in St. Louis on November 18-19, 2013. The workshop examined a wide array of challenges and progress in water quality monitoring and evaluation in states along the Mississippi River corridor, and provided a forum for experts from U.S. federal agencies, the Mississippi River states, nongovernmental organizations, and the private sector to share and compare monitoring and evaluation experiences from their respective organizations.