This two-volume set LNCS 14859-14860 constitutes the proceedings of the 28th Annual Conference on Medical Image Understanding and Analysis, MIUA 2024, held in Manchester, UK, during July 24–26, 2024.

The 59 full papers included in this book were carefully reviewed and selected from 93 submissions. They were organized in topical sections as follows:

Part I

 Advancement in Brain Imaging; Medical Images and Computational Models; and Digital Pathology, Histology and Microscopic Imaging.

Part II

 Dental and Bone Imaging; Enhancing Low-Quality Medical Images; Domain Adaptation and Generalisation; and Dermatology, Cardiac Imaging and Other Medical Imaging.