After avenging the death of their father, the McCullough girls are left alone to run their cattle ranch.

In order to keep their ranch alive, they must drive their herd to market in Kansas. They hire an old Buffalo Soldier named Buford Riley, nicknamed Bo, as their ramrod.

Among the many perils on the trail was a family that had been beaten and murdered.

There was one surviving member, a young girl that had been beaten, raped, and left for dead. The girls rescue her and nurse her back to health. She becomes as close as the sister they lost in the fight with their fathers' murderers.

A chance meeting with one of the men that left the young girl for dead results in a fierce and costly gun battle at the end of their drive.