This two-volume set constitutes the refereed proceedings of the Third International Conference, ISDS 2025, held in Can Tho City, Vietnam, during October 18–19, 2025.The 67 full papers and 2 Short papers included in this book were carefully reviewed and selected from 181 submissions. They focus on the development of innovative, interpretable, and explainable data science and artificial intelligence technologies. They were organized in topical sections as follows:Part I: Intelligent Systems and Data Science (CCIS 2714).Part II: Intelligent Systems and Data Science (CCIS 2716).