This book constitutes the proceedings of the 22nd International Conference on Information Security, ISC 2019, held in New York City, NY, USA, in September 2019.

The 23 full papers presented in this volume were carefully reviewed and selected from 86 submissions. The papers were organized in topical sections named:

Attacks and Cryptanalysis

Crypto I: Secure Computation and Storage

Machine Learning and Security

 Crypto II: Zero-Knowledge Proofs

Defenses

Web Security

Side Channels

 Malware Analysis

Crypto III: Signatures and Authentication