This book constitutes the refereed proceedings of the 18th International Conference on Hybrid Artificial Intelligent Systems, HAIS 2023, held in Salamanca, Spain, during September 5–7, 2023.

The 65 full papers included in this book were carefully reviewed and selected from 120 submissions. They were organized in topical sections as follows: Anomaly and Fault Detection, Data Mining and Decision Support Systems, Deep Learning, Evolutionary Computation and Optimization, HAIS Applications, Image and Speech Signal Processing, Agents and Multiagents, Biomedical Applications.