This book comprises a selection of articles from the 13th World Conference on Information Systems and Technologies (WorldCIST’25), held from April 15 to 17, 2025, at the Federal University of Santa Catarina, Florianópolis, Brazil.WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences, and the challenges of modern research in Information Systems and Technologies, along with their technological developments and applications.The main and distinctive topics covered include:A) Information and Knowledge ManagementB) Organizational Models and Information SystemsC) Software and Systems ModelingD) Software Systems, Architectures, Applications, and ToolsE) Multimedia Systems and ApplicationsF) Computer Networks, Mobility, and Pervasive SystemsG) Intelligent and Decision Support SystemsH) Big Data Analytics and ApplicationsI) Human–Computer InteractionJ) Ethics, Computers, and  SecurityK) Health InformaticsL) Information Technologies in EducationM) Information Technologies in RadiocommunicationsN) Technologies for Biomedical ApplicationsThe primary target audience for this book is postgraduate students and researchers in the field of Information Systems and Technologies. The secondary audience includes undergraduate students and professionals in the same field.