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Drug Targeting
Strategies, Principles, and Applications
Advances in understanding the molecular mechanisms of disease
Together with the advent of recombinant DNA and other technologies, these advances have opened opportunities for a vast array of novel therapeutic biopharmaceuticals and diagnostic agents. However, even natural biomolecules present a myriad of problems that limit their potential as pharmaceutical agents. Rapid degradation and elimination, immunological reactions, and toxicity are often associated with new biopharmaceuticals, much as with conventional agents.
Targeted delivery systems
These systems have the potential to increase the efficacy of existing diagnostic and therapeutic agents and also create an opportunity for the use of new pharmaceuticals, substances that themselves can be harmful to normal tissues. Both passive and active targeting have been exploited. Most active targeting strategies have focused on antibody conjugates since preparation of highly specific monoclonal antibodies is well established. However, a new wave of conjugates exploiting other ligands is underway.
Challenges and approaches
Access to the target tissue remains an obstacle and is an area where passive targeting can be useful. In Drug Targeting: Strategies, Principles, and Applications, we have tried to compile a state-of-the-art volume on current targeting approaches. The first section focuses on certain key strategies applied to date, and how to build the antibody–ligand constructs. This is followed by a section on theoretical considerations for targeting, focusing on approaches relevant to solid tumors. The last section deals with some experimental and clinical applications of targeted drug delivery systems.
