This book constitutes the proceedings of the Second refereed proceedings of the Second International Conference on Data Science and Artificial Intelligence, DSAI 2024, held in Medan, Indonesia, during November 13–15, 2024.

The 18 full papers, 2 short papers and 3 invited talks were included in this book were carefully reviewed and selected from 69 submissions. They are organized in the following topical sections: Keynote Presentations; Natural and Sign Language Processing; Applications of Data Science and Artificial Intelligence; Affective Computing and AI Games; Embedded AI and Applications; Data Science; AI and Healthcare.