The three-volume set CCIS 2681–2683 constitutes the post-conference proceedings of the First International Conference on Data Science, Artificial Intelligence and Applications, ICDSAIA 2025, held in Dhaka, Bangladesh, during July 18–19, 2025.The 99 full papers included in this book were carefully reviewed and selected from 190 submissions. They focus on latest advancements in data science, artificial intelligence (AI), and their applications across diverse sectors—including healthcare, education, finance, governance, agriculture, and sustainable development—highlighting its potential to solve pressing societal challenges and accelerate progress toward the Sustainable Development Goals (SDGs).