This book explores the early evangelical quest for enlightenment by the Spirit and the Word. While the pursuit originated in the Protestant Reformation, it assumed new forms in the long eighteenth-century context of the early Enlightenment and transatlantic awakened Protestant reform. This work illuminates these transformations by focusing on the dynamic intersection of experimental philosophy and experimental religion in the biblical practices of early America’s most influential Protestant theologians, Cotton Mather (1663-1728) and Jonathan Edwards (1703-1758). As the first book-length project to treat Mather and Edwards together, this study makes an important contribution to the extensive scholarship on these figures, opening new perspectives on the continuities and complexities of colonial New England religion. It also provides new insights and interpretive interventions concerning the history of the Bible, early modern intellectual history, and evangelicalism’s complex relationship to the Enlightenment.