Caught between an ambitious Major Fenwick, commander of Fort Hughes, and Chief Horse Who Runs On Tiptoes, leader of a small band of renegade Cheyenne, Casey Beymer is forced to teach those Cheyenne how to play baseball in order to save his own neck. At first the Indians are reluctant to learn the white mans game, but then Casey finds the secret to arousing their boundless enthusiasm.

When the Fort Hughes team succumbs to smallpox just before a high-stakes Fourth of July game in Denver, the Cheyenne, and Casey, are drafted to replace them---with startling results.