Introduction

This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice).

Transition from IgG Substitution to Immunomodulation

The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases.

Basic Aspects of IgG Concentrates

Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed.

Immunomodulatory IgG Treatment in ITP

An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP).

Transition to Monoclonal Antibody Treatment

Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.