This book is a collection of peer-reviewed best selected research papers presented at the Sixth International Conference on Advances in Distributed Computing and Machine Learning (ICADCML 2025), organized by Dept. of Computer Science and Information Engineering, National Taiwan University of Science and Technology, Taiwan during January 9–10, 2025. This book presents recent innovations in the field of scalable distributed systems in addition to cutting-edge research in the field of Internet of Things (IoT) and blockchain in distributed environments. The work is presented in two volumes.